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Researchers should note that the receptor mediating the IGF-1R-independent effects of the MGF E-peptide has not been formally identified, and that independent replication of some proliferative effects has been inconsistent across cell culture systems — both of which are accurately reflected in the published literature and should inform experimental design

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In activated T cells, metabolic fitness and synthetic function has been directly linked to G6PD activity and ROS homeostasis by Ghergurovich and colleagues, who used a novel metabolite reporter and deuterium tracer assays to monitor cellular G6PD activity in the presence of a specific potent inhibitor of G6PD (55)